VPS36

Protein-coding gene in the species Homo sapiens

VPS36

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2HTH, 2ZME, 3CUQ

Identifiers

Aliases

VPS36, C13orf9, EAP45, CGI-145, vacuolar protein sorting 36 homolog

External IDs

OMIM: 610903; MGI: 1917410; HomoloGene: 9374; GeneCards: VPS36; OMA:VPS36 - orthologs

Gene location (Human)

Chr.	Chromosome 13 (human)^[1]

Band	13q14.3	Start	52,412,602 bp^[1]
Band	13q14.3	End	52,450,634 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 A2	Start	22,682,825 bp^[2]
Band	8\|8 A2	End	22,710,859 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

skin of arm

mucosa of ileum

skin of hip

skin of thigh

pancreatic epithelial cell

pancreatic ductal cell

tibialis anterior muscle

endothelial cell

skin of abdomen

gingival epithelium

Top expressed in

trigeminal ganglion

urothelium

transitional epithelium of urinary bladder

Paneth cell

hair follicle

ureter

medullary collecting duct

otic vesicle

endocardial cushion

spermatid

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	phosphatidylinositol-3-phosphate binding protein C-terminus binding ubiquitin binding protein binding lipid binding
Cellular component	cytoplasm cytosol late endosome membrane late endosome membrane lysosome extracellular exosome nucleus endosome ESCRT II complex
Biological process	regulation of transcription, DNA-templated multivesicular body assembly transcription, DNA-templated endosomal transport protein transport protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway macroautophagy transport endosome transport via multivesicular body sorting pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


51028


70160

Ensembl


ENSG00000136100


ENSMUSG00000031479

UniProt


Q86VN1


Q91XD6

RefSeq (mRNA)


NM_016075 NM_001282168 NM_001282169


NM_027338 NM_001368379

RefSeq (protein)


NP_001269097 NP_001269098 NP_057159


NP_081614 NP_001355308

Location (UCSC)

Chr 13: 52.41 – 52.45 Mb

Chr 8: 22.68 – 22.71 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Vacuolar protein-sorting-associated protein 36 is a protein that in humans is encoded by the VPS36 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136100 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031479 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kamura T, Burian D, Khalili H, Schmidt SL, Sato S, Liu WJ, Conrad MN, Conaway RC, Conaway JW, Shilatifard A (May 2001). "Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose". J Biol Chem. 276 (19): 16528–33. doi:10.1074/jbc.M010142200. PMID 11278625.
^ Slagsvold T, Aasland R, Hirano S, Bache KG, Raiborg C, Trambaiolo D, Wakatsuki S, Stenmark H (May 2005). "Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain". J Biol Chem. 280 (20): 19600–6. doi:10.1074/jbc.M501510200. PMID 15755741.
^ "Entrez Gene: VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae)".

Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570.
Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. Bibcode:2003PNAS..10012414M. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bowers K, Piper SC, Edeling MA, et al. (2006). "Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII". J. Biol. Chem. 281 (8): 5094–105. doi:10.1074/jbc.M508632200. PMID 16371348.
Alam SL, Langelier C, Whitby FG, et al. (2007). "Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain". Nat. Struct. Mol. Biol. 13 (11): 1029–30. doi:10.1038/nsmb1160. PMID 17057716. S2CID 41152121.

PDB gallery

2dx5: The complex structure between the mouse EAP45-GLUE domain and ubiquitin
2hth: Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain