URG4

Protein-coding gene in the species Homo sapiens

URGCP

Identifiers

Aliases

URGCP, URG4, upregulator of cell proliferation

External IDs

OMIM: 610337; MGI: 1919296; HomoloGene: 69243; GeneCards: URGCP; OMA:URGCP - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7p13	Start	43,875,894 bp^[1]
Band	7p13	End	43,926,411 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 A1	Start	5,663,417 bp^[2]
Band	11\|11 A1	End	5,712,376 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right adrenal cortex

left adrenal gland

left adrenal cortex

apex of heart

cerebellar hemisphere

right hemisphere of cerebellum

glutes

triceps brachii muscle

gastrocnemius muscle

pituitary gland

Top expressed in

substantia nigra

otolith organ

utricle

Paneth cell

Rostral migratory stream

ciliary body

iris

fossa

condyle

retinal pigment epithelium

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	GTP binding
Cellular component	cytoplasm nucleus cytosol
Biological process	cell cycle
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


55665


72046

Ensembl


ENSG00000106608


ENSMUSG00000049680

UniProt


Q8TCY9


Q5NCI0

RefSeq (mRNA)


NM_017920 NM_001077663 NM_001077664 NM_001290075 NM_001290076

NM_001077661 NM_178623 NM_001361588 NM_001361589 NM_001361590
NM_001361591 NM_001361592

RefSeq (protein)


NP_001071131 NP_001071132 NP_001277004 NP_001277005 NP_060390

NP_001071129 NP_848738 NP_001348517 NP_001348518 NP_001348519
NP_001348520 NP_001348521

Location (UCSC)

Chr 7: 43.88 – 43.93 Mb

Chr 11: 5.66 – 5.71 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Up-regulated gene 4, also known as URG4, is a human gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106608 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049680 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: URG4 up-regulated gene 4".

Song J, Xie H, Lian Z, Yang G, Du R, Du Y, Zou X, Jin H, Gao J, Liu J, Fan D (December 2006). "Enhanced cell survival of gastric cancer cells by a novel gene URG4". Neoplasia. 8 (12): 995–1002. doi:10.1593/neo.06592. PMC 1783723. PMID 17217616.
Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM (September 2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Fu GK, Wang JT, Yang J, Au-Young J, Stuve LL (July 2004). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
Tufan NL, Lian Z, Liu J, Pan J, Arbuthnot P, Kew M, Clayton MM, Zhu M, Feitelson MA (2003). "Hepatitis Bx antigen stimulates expression of a novel cellular gene, URG4, that promotes hepatocellular growth and survival". Neoplasia. 4 (4): 355–68. doi:10.1038/sj.neo.7900241. PMC 1531705. PMID 12082552.
Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.