Sulfadoxine
Chemical compound
- QJ01EQ13 (WHO)
- 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
- 2447-57-6 Y
- 17134
- DB01299 N
- 16218 N
- 88463U4SM5
- D00580 Y
- ChEMBL1539 N
- 007816
- DTXSID6023608
- Interactive image
- COC1=C(N=CN=C1OC)NS(=O)(=O)C2=CC=C(C=C2)N
Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide used in combination with pyrimethamine to treat malaria.[1]
It is also used to prevent malaria[2] but due to high levels of sulphadoxine-pyrimethamine resistance, this use has become less common.[3]
It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.[citation needed]
Mechanism of action
Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.[citation needed]
See also
References
Scholia has a topic profile for Sulfadoxine.
- ^ Medical Treatment - Sulphadoxine and Pyrimethamine Archived 2007-12-28 at the Wayback Machine.
- ^ "WHO | Intermittent preventive treatment in pregnancy (IPTp)". Who.int. Archived from the original on March 5, 2014. Retrieved 27 November 2021.
- ^ Matondo SI, Temba GS, Kavishe AA, et al. (2014). "High levels of sulphadoxine-pyrimethamine resistance Pfdhfr-Pfdhps quintuple mutations: a cross sectional survey of six regions in Tanzania". Malar J. 13: 152. doi:10.1186/1475-2875-13-152. PMC 3998221. PMID 24751352.
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(inhibit bacterial
purine metabolism,
thereby inhibiting
DNA and RNA
synthesis)
DHFR inhibitor | |||||||||
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Sulfonamides (DHPS inhibitor) |
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Combinations |
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Other DHPS inhibitors |
(inhibit bacterial
topoisomerase
and/or DNA gyrase,
thereby inhibiting
DNA replication)
1st generation | |||||||||
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Fluoroquinolones |
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Newer non-fluorinated | |||||||||
Related (DG) |
inhibitors
Nitroimidazole derivatives | |
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Nitrofuran derivatives |
Rifamycins/ RNA polymerase | |
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Lipiarmycins |
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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