Myod family inhibitor domain containing

MDFIC
Identifiers
Aliases	MDFIC, HIC, MyoD family inhibitor domain containing, MDFIC1
External IDs	OMIM: 614511; MGI: 104611; HomoloGene: 18404; GeneCards: MDFIC; OMA:MDFIC - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q31.1-q31.2 Start 114,922,094 bp[1] End 115,019,917 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A1 Start 15,720,660 bp[2] End 15,802,168 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid tibia Epithelium of choroid plexus lactiferous duct skin of hip visceral pleura germinal epithelium mucosa of paranasal sinus periodontal fiber oral cavity Top expressed in Epithelium of choroid plexus cumulus cell epithelium of lens ciliary body stroma of bone marrow iris right lung lobe choroid plexus of fourth ventricle conjunctival fornix calvaria More reference expression data BioGPS n/a
Gene ontology Molecular function transcription factor binding Tat protein binding protein binding cyclin binding Cellular component nucleolus nucleus cytoplasm Golgi apparatus nucleoplasm Biological process positive regulation of transcription, DNA-templated positive regulation of viral transcription regulation of Wnt signaling pathway viral process regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of protein import into nucleus negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29969 16543 Ensembl ENSG00000135272 ENSMUSG00000041390 UniProt Q9P1T7 Q8BX65 RefSeq (mRNA) NM_199072 NM_001166345 NM_001166346 NM_175088 RefSeq (protein) NP_001159817 NP_001159818 NP_951038 NP_780297 Location (UCSC) Chr 7: 114.92 – 115.02 Mb Chr 6: 15.72 – 15.8 Mb PubMed search [3] [4]
Wikidata
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MyoD family inhibitor domain containing is a protein that in humans is encoded by the MDFIC gene. ^[5]

Function

This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.