Protein-coding gene in the species Homo sapiens
| MUC2 |
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| Identifiers |
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| Aliases | MUC2, MLP, MUC-2, SMUC, mucin 2, oligomeric mucus/gel-forming |
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| External IDs | OMIM: 158370; MGI: 1339364; HomoloGene: 136755; GeneCards: MUC2; OMA:MUC2 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 11 (human)[1] |
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| | Band | 11p15.5 | Start | 1,074,875 bp[1] |
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| End | 1,110,511 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 7 (mouse)[2] |
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| | Band | 7 F5|7 87.1 cM | Start | 141,276,583 bp[2] |
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| End | 141,308,430 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - mucosa of transverse colon
- rectum
- duodenum
- appendix
- epithelium of colon
- smooth muscle tissue
- olfactory zone of nasal mucosa
- muscle layer of sigmoid colon
- right coronary artery
- urinary bladder
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| | Top expressed in | - jejunum
- colon
- ileum
- duodenum
- neural layer of retina
- urinary bladder
- zygote
- tail of embryo
- embryo
- embryo
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | | | Cellular component | - extracellular region
- outer mucus layer
- Golgi lumen
- inner mucus layer
- mucus layer
- plasma membrane
- collagen-containing extracellular matrix
| | Biological process | - O-glycan processing
- maintenance of gastrointestinal epithelium
- stimulatory C-type lectin receptor signaling pathway
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 11: 1.07 – 1.11 Mb | Chr 7: 141.28 – 141.31 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Mucin 2, oligomeric mucus gel-forming, also known as MUC2, is a protein that in humans is encoded by the MUC2 gene.[5][6]
Function
This gene encodes a member of the mucin protein family. The protein encoded by this gene, also called mucin 2, is secreted onto mucosal surfaces.[5]
Mucin 2 is particularly prominent in the gut where it is secreted from goblet cells in the epithelial lining into the lumen of the large intestine. There, mucin 2, along with small amounts of related-mucin proteins, polymerizes into a gel of which 80% by weight is oligosaccharide side-chains that are added as post-translational modifications to the mucin proteins. This gel provides an insoluble mucous barrier that serves to protect the intestinal epithelium.
Genetics
The mucin 2 protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000198788 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025515 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Allen A, Hutton DA, Pearson JP (July 1998). "The MUC2 gene product: a human intestinal mucin". Int. J. Biochem. Cell Biol. 30 (7): 797–801. doi:10.1016/S1357-2725(98)00028-4. PMID 9722984.
- ^ Rousseau K, Byrne C, Kim YS, Gum JR, Swallow DM, Toribara NW (May 2004). "The complete genomic organization of the human MUC6 and MUC2 mucin genes". Genomics. 83 (5): 936–9. doi:10.1016/j.ygeno.2003.11.003. PMID 15081123.
- ^ "Entrez Gene: MUC2 mucin 2, oligomeric mucus/gel-forming".
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