Protein-coding gene in the species Homo sapiens
HEPACAM2 |
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Identifiers |
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Aliases | HEPACAM2, MIKI, HEPACAM family member 2 |
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External IDs | OMIM: 614133; MGI: 2141520; HomoloGene: 18724; GeneCards: HEPACAM2; OMA:HEPACAM2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 7 (human)[1] |
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| Band | 7q21.2 | Start | 93,188,534 bp[1] |
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End | 93,226,469 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 6 (mouse)[2] |
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| Band | 6|6 A1 | Start | 3,457,096 bp[2] |
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End | 3,498,298 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - mucosa of ileum
- mucosa of sigmoid colon
- rectum
- islet of Langerhans
- palpebral conjunctiva
- mucosa of transverse colon
- jejunal mucosa
- testicle
- duodenum
- human kidney
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| Top expressed in | - islet of Langerhans
- left colon
- crypt of lieberkuhn of small intestine
- ileum
- jejunum
- duodenum
- intestinal villus
- Paneth cell
- right kidney
- spermatocyte
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | | Cellular component | - cytoplasm
- microtubule organizing center
- integral component of membrane
- Golgi membrane
- centrosome
- cytoskeleton
- membrane
- Golgi apparatus
- spindle
- midbody
| Biological process | - cell cycle
- cell division
- centrosome cycle
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001039372 NM_001288804 NM_001288810 NM_198151 NM_001346642 |
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RefSeq (protein) | |
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NP_001034461 NP_001275733 NP_001275739 NP_001333571 NP_937794 |
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Location (UCSC) | Chr 7: 93.19 – 93.23 Mb | Chr 6: 3.46 – 3.5 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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HEPACAM family member 2 is a protein that in humans is encoded by the HEPACAM2 gene. [5]
Function
This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology, and apoptosis.
Poly (ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000188175 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044156 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: HEPACAM family member 2". Retrieved 2017-09-13.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.