Ets variant 3

Protein-coding gene in the species Homo sapiens
ETV3
Identifiers
AliasesETV3, METS, PE-1, PE1, bA110J1.4, ETS variant 3, ETS variant transcription factor 3
External IDsOMIM: 164873; MGI: 1350926; HomoloGene: 21085; GeneCards: ETV3; OMA:ETV3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ETV3
Genomic location for ETV3
Band1q23.1Start157,121,191 bp[1]
End157,138,474 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for ETV3
Genomic location for ETV3
Band3|3 F1Start87,432,714 bp[2]
End87,447,463 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of arm

  • skin of thigh

  • skin of hip

  • gingival epithelium

  • jejunal mucosa

  • palpebral conjunctiva

  • corpus epididymis

  • cardiac muscle tissue of right atrium

  • tail of epididymis

  • amniotic fluid
Top expressed in
  • mesenteric lymph nodes

  • hair follicle

  • skin of back

  • skin of external ear

  • left colon

  • Rostral migratory stream

  • olfactory epithelium

  • subcutaneous adipose tissue

  • left lung lobe

  • cumulus cell
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • DEAD/H-box RNA helicase binding
  • DNA binding
  • sequence-specific DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • molecular function
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • RNA polymerase II transcription repressor complex
  • transcription repressor complex
  • nucleus
Biological process
  • regulation of transcription by RNA polymerase II
  • cell differentiation
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • cellular response to granulocyte macrophage colony-stimulating factor stimulus
  • transcription, DNA-templated
  • negative regulation of cell population proliferation
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2117

27049

Ensembl

ENSG00000117036

ENSMUSG00000003382

UniProt

P41162

Q8R4Z4

RefSeq (mRNA)

NM_001145312
NM_005240

NM_001083318
NM_001286844
NM_012051
NM_001359750

RefSeq (protein)

NP_001138784
NP_005231

NP_001076787
NP_001273773
NP_036181
NP_001346679

Location (UCSC)Chr 1: 157.12 – 157.14 MbChr 3: 87.43 – 87.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ets variant 3 is a protein that in humans is encoded by the ETV3 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117036 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003382 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Ets variant 3".

Further reading

  • Klemsz M, Hromas R, Raskind W, Bruno E, Hoffman R (March 1994). "PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23". Genomics. 20 (2): 291–4. doi:10.1006/geno.1994.1169. PMID 8020980.
  • Hester KD, Verhelle D, Escoubet-Lozach L, Luna R, Rose DW, Glass CK (July 2007). "Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS". Cell Cycle. 6 (13): 1594–604. doi:10.4161/cc.6.13.4336. PMID 17525531.
  • Anney RJ, Lasky-Su J, O'Dúshláine C, Kenny E, Neale BM, Mulligan A, Franke B, Zhou K, Chen W, Christiansen H, Arias-Vásquez A, Banaschewski T, Buitelaar J, Ebstein R, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen H, Asherson P, Faraone SV, Gill M (December 2008). "Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 147B (8): 1369–78. doi:10.1002/ajmg.b.30871. PMID 18951430. S2CID 30325260.
  • Sawka-Verhelle D, Escoubet-Lozach L, Fong AL, Hester KD, Herzig S, Lebrun P, Glass CK (April 2004). "PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation". The Journal of Biological Chemistry. 279 (17): 17772–84. doi:10.1074/jbc.M311991200. PMID 14754893.
  • Klappacher GW, Lunyak VV, Sykes DB, Sawka-Verhelle D, Sage J, Brard G, Ngo SD, Gangadharan D, Jacks T, Kamps MP, Rose DW, Rosenfeld MG, Glass CK (April 2002). "An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation". Cell. 109 (2): 169–80. doi:10.1016/S0092-8674(02)00714-6. PMID 12007404. S2CID 16359491.
  • Mesquita B, Lopes P, Rodrigues A, Pereira D, Afonso M, Leal C, Henrique R, Lind GE, Jerónimo C, Lothe RA, Teixeira MR (February 2013). "Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes". Breast Cancer Research and Treatment. 138 (1): 37–45. doi:10.1007/s10549-013-2408-2. PMID 23329352. S2CID 23604624.
  • El Kasmi KC, Smith AM, Williams L, Neale G, Panopoulos AD, Panopolous A, Watowich SS, Häcker H, Foxwell BM, Murray PJ (December 2007). "Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway". Journal of Immunology. 179 (11): 7215–9. doi:10.4049/jimmunol.179.11.7215. PMID 18025162.
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